The Breakthrough in Enzyme-Based Therapeutics

In the rapidly evolving fields of biomedicine and cosmetic science, Proteos Biotech has emerged as a pioneering force since its founding in 2010. Specializing in recombinant enzyme technology, the company has achieved strong and continuous growth, establishing itself as a global reference in advanced therapeutic solutions. At the heart of this success lies PB Serum with HA 2.0, the first-ever therapeutic system based on recombinant enzymes, which has revolutionized patient care by delivering unprecedented skin regeneration and rejuvenation.

Available in low, medium, and high concentrations, PB Serum with HA 2.0 combines next-generation hyaluronic acid (HA 2.0) with bioengineered enzymes to create a powerful, science-backed treatment that enhances cellular repair, hydration, and anti-aging effects. This article explores the science behind PB Serum, its unique benefits, and why it represents a quantum leap in skincare and therapeutic medicine.

Why PB Serum is Revolutionary

PB Serum is revolutionary because it represents the first-ever therapeutic system harnessing the power of recombinant enzymes combined with next-generation hyaluronic acid (HA 2.0). Unlike conventional skincare that merely sits on the skin’s surface, PB Serum works at a cellular level to actively remodel tissue structure. Its proprietary enzyme blend – including Collagenase G/H PB220 for collagen restructuring and Lipase PB500 for targeted fat reduction – delivers unprecedented precision in aesthetic medicine. The advanced HA 2.0 technology provides immediate hydration while creating an optimal environment for enzymatic activity. What truly sets PB Serum apart is its dual-action mechanism: it offers both instant visible improvements and progressive, long-term tissue regeneration. Available in three customizable concentrations, it addresses everything from preventive care to intensive rejuvenation with clinically proven efficacy. By bridging the gap between cosmetic treatments and true cellular therapy, PB Serum has redefined the possibilities of non-invasive skin rejuvenation and body contouring.

How PB Serum Compares to Traditional Skincare

Feature	PB Serum with HA 2.0	Traditional HA Serums	Peptide-Based Serums
Active Technology	Recombinant Enzymes + HA 2.0	Standard HA	Synthetic Peptides
Depth of Action	Cellular Level (Dermis)	Surface-Level (Epidermis)	Mid-Dermal Penetration
Results Timeline	Immediate + Long-Term	Temporary Plumping	Gradual (Weeks-Months)
Collagen Stimulation	High (Enzyme-Activated)	Minimal	Moderate
Customization	Yes (3 Strengths)	No	Limited

PB Serum outperforms conventional options by merging rapid hydration with true skin remodeling.

2nd Generation Enzymes Ready To Use, Easy To Apply and Minimally Invasive Device 

Proteos Biotech’s innovative treatment products are designed for specific clinical indications, combining high-molecular-weight hyaluronic acid (HMW-HA) with precision-engineered enzymes to deliver transformative results. These formulations address fibrosis prevention, collagen remodeling, fluid retention, and localized fat reduction, offering a comprehensive, science-backed approach to aesthetic and therapeutic medicine.

1. HMW-HA: The Anti-Fibrotic Barrier

High-molecular-weight hyaluronic acid (HMW-HA) plays a pivotal role in fibrosis prevention and treatment. Its unique viscoelastic properties create a physical barrier that:
✔ Prevents abnormal tissue adhesion (post-surgical/traumatic fibrosis).
✔ Reduces scar tissue formation by modulating fibroblast activity.
✔ Enhances tissue hydration while maintaining structural integrity.

This makes HMW-HA an essential component in post-operative recovery and anti-scarring therapies.

2. Lyase PB72K: Breaking Down Fluid Retention & Enhancing Diffusion

Lyase PB72K is a recombinant enzyme specifically engineered to:
✔ Degrade polysaccharides responsible for edema and fluid retention.
✔ Improve tissue permeability, facilitating the diffusion of active molecules (e.g., peptides, growth factors).
✔ Stimulate long-term tissue remodeling by optimizing extracellular matrix (ECM) turnover.

This enzyme is particularly effective in treating post-inflammatory swelling and enhancing the efficacy of co-administered therapeutics.

3. Collagenase G/H PB220: Restructuring Collagen for Firmer Skin

Collagenase G/H PB220 selectively targets:
✔ Non-functional (amorphous) collagen fibers—breaking them down to eliminate damaged ECM.
✔ Stimulates neocollagenesis (new collagen production) for long-term skin tightening.
✔ Improves skin texture and elasticity by promoting organized, functional collagen networks.

This enzyme is ideal for treating aged, sun-damaged, or scarred skin, where collagen restructuring is needed.

4. Lipase PB500: Non-Destructive Fat Reduction

Unlike traditional fat-dissolving treatments that disrupt cell membranes, Lipase PB500 works intracellularly:
✔ Penetrates adipocytes without cell lysis (prevents inflammation).
✔ Breaks down triglycerides into free fatty acids, gradually reducing fat cell volume.
✔ Supports natural metabolic clearance of lipids, ensuring smooth, natural-looking contouring.

This makes it a safer, more controlled alternative to conventional lipolytic therapies.

Final Thought 

PB Serum’s status as the first-ever therapeutic enzyme system marks a pivotal advancement in aesthetic medicine. Its importance lies in fundamentally changing how we approach skin and tissue rejuvenation – shifting from temporary cosmetic fixes to true biological remodeling. By combining recombinant enzymes with advanced HA 2.0, it achieves what no single-ingredient product can: simultaneous immediate improvement and long-term structural regeneration. This breakthrough matters because it offers physicians and patients a science-backed alternative to invasive procedures, with customizable treatments for various aging concerns. The enzymatic precision targets specific tissue components (collagen, fat, polysaccharides) without damaging surrounding structures, representing a new standard in safety and efficacy. More than just another skincare product, PB Serum establishes a new category of “enzyme therapeutics” that bridges the gap between dermatology and regenerative medicine. Its development proves that cutting-edge biotechnology can create solutions that work in harmony with the body’s natural processes, setting a new benchmark for future innovations in the field.