Aesthetic Treatments: Wrinkles, Fine Lines

BTA

Botulinum Toxin Type A (BTA) is a purified protein from the bacterium Clostridium Botulinum that effectively and safely:

  • blocks nerve impulses responsible for wrinkles formation at the forehead, frown lines and crow’s feet areas.
  • reduces bulky masseter muscles (chewing muscles) to create V-shaped face by reducing square jawline.

Unlike other invasive procedures, BTA is relatively safe as it is reversible and of non-permanent effect. BTA is virtually painless method towards a youthful and radiant skin.

We currently have 2 BTA types:

  • onabotulinumtoxinA (Botox®; Botox Cosmetic, Allergan, Irvine, CA, USA),
  • incobotulinumtoxinA (Xeomin®; Merz Pharmaceuticals, Frankfurt, Germany)

Xeomin®

1. What is Xeomin®?

Xeomin® is a prescription medication injected into muscles and used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. Xeomin® contains botulinum toxin type A, a protein purified from the bacterium Clostridium Botulinum.

2. What are the results?

You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week.

The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

3. How safe is the treatment?

Xeomin® was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years.

Patients received 20 Units of Xeomin® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient.

Using these criteria, treatment success was higher with Xeomin® than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies).

Based on these trials, Xeomin® received FDA approval for use in glabellar lines in 2011.

4. How is Xeomin® different from other brands?

Xeomin® is made through a unique precision manufacturing process that isolates the therapeutic component of the molecule and removes the accessory proteins that don’t play an active role in treatment.

Xeomin® is a highly purified neurotoxin. Studies have not been performed to determine whether the presence or absence of accessory proteins has a long-term effect on safety or efficacy.

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